David Melton
University of Edinburgh
Old College
South Bridge
Edinburgh
EH8 9YL
United Kingdom
Email: david.melton@ed.ac.uk
Tel: 0131 651 1079
Web: Lab website
Scientific summary
The aim is to understand the complex relationship between DNA repair and cancer: DNA repair deficiency results in increased susceptibility to cancer, while DNA repair in cancer cells reduces the effectiveness of many cancer chemotherapeutics.
Recent publications
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable
Mol Cell Biol.2003;23 :9245-9250
Multiple Roles of the ERCC1-XPF Endonuclease in DNA Repair and Resistance to Anticancer Drugs
Anticancer Res.2010;30 :3223-3232
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