Cancer Research UK - Chromosome Replication

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Photos from 2005 Retreat

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INTRODUCTION

In the Chromosome Replication Laboratory, we are interested in understanding the mechanisms and regulation of DNA replication in eukaryotic cells at a molecular level. Much of our work has used the budding yeast Saccharomyces cerevisiae which has proved to be an excellent model system. Although most of the laboratory still studies replication in budding yeast, we are now extending our work to study DNA replication in human cells.

Group at 2005 Retreat. Photo by Rajat Roy. From left to right: Lucy Drury, Minna Mäkiniemi, John Diffley, Anne Early, Monica Segurado Carrascal, Phil Zegerman, Niels Mailand, Christian Zierhut, Jonathan Baxter, Keiichi Watanabe, Satoru Mimura. Missing from Photo: Dirk Remus and Rajat Roy

Rajat Roy, photographer and scientist

CURRENT RESEARCH

Some specific areas of current research include:

The molecular mechanisms involved in initiating DNA replication.
How DNA replication is limited to once per cell cycle in both budding yeast and human cells.
The consequences of misregulating DNA replication on genome stability.
How DNA replication is regulated in response to DNA damage.

OPPORTUNITIES

If you find any of the projects described here interesting and would like to join the lab either as a postdoctoral fellow or as a Ph.D. student, contact John Diffley. Please include your current CV in the email.

To learn more about Clare Hall Laboratories and the London Research Institute, follow the links below:

The London Research Institute
Clare Hall Laboratories

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Page updated 19/09/2005

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