Selected publications before 2000
1. Diffley, J.F.X., and Cocker, J.H. (1992). Protein-DNA interactions at a yeast replication origin. Nature 357, 169-172.
2. Micklem, G., Rowley, A., Harwood, J., Nasmyth, K., and Diffley, J.F.X. (1993). Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366, 87-89.
3. Diffley, J.F.X., Cocker, J.H., Dowell, S.J., and Rowley, A. (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.
4. Dowell, S.J., Romanowski, P., and Diffley, J.F.X. (1994). Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265, 1243-1246.
5.Dahmann, C., Diffley, J.F.X., and Nasmyth, K.A. (1995). S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of origins to a pre-replicative state. Curr. Biol. 5, 1257-1269.
6. Cocker, J.H., Piatti, S., Santocanale, C., Nasmyth, K., and Diffley, J.F.X. (1996). An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379, 180-182.
7. Donovan, S., and Diffley, J.F.X. (1996). Replication Origins in Eukaryotes. Curr. Opin. Genet. Dev. 6, 203-207.
8. Santocanale, C., and Diffley, J.F.X. (1996). ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J. 15, 6671-6679.
9. Donovan, S., Harwood, J., Drury, L.S., and Diffley, J.F.X. (1997). Cdc6-Dependent Loading of Mcm Proteins onto Pre-replicative Chromatin in Budding Yeast. Proc. Natl. Acad. Sci. USA 94, 5611-5616.
10. Bousset, K., and Diffley, J.F.X. (1998). The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev. 12, 480-490.
11. Desdouets, C., Santocanale, C., Drury, L.S., Perkins, G., Foiani, M., Plevani, P., and Diffley, J.F.X. (1998). Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase a. EMBO J. 17, 4139-4146.
12. Santocanale, C., and Diffley, J.F.X. (1998). A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395, 615-618.
13. Labib, K., Diffley, J.F.X., and Kearsey, S.E. (1999). G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat. Cell Biol. 1, 415-422.
14. Santocanale, C., Sharma, K., and Diffley, J.F.X. (1999). Activation of dormant origins of DNA replication in budding yeast. Genes Dev. 13, 2360-2364.
Publications since 2000
15. Diffley, J.F.X., Bousset, K., Labib, K., Noton, E.A., Santocanale, C., and Tercero, J.A. (2000). Coping with and Recovering from Hydroxyurea-Induced Replication Fork Arrest in Budding Yeast. Cold Spring Harbor Symp. Quant. Biol. 65, 333-342.
16. Drury, L.S., Perkins, G., and Diffley, J.F.X. (2000). The Cyclin Dependent Kinase Cdc28p Regulates Distinct Modes of Cdc6p Proteolysis during the Budding Yeast Cell Cycle. Curr. Biol. 10, 231-240.
17. Godinho Ferreira, M., Santocanale, C., Drury, L.S., and Diffley, J.F.X. (2000). Dbf4p, an essential S phase promoting factor, is targeted for degradation by the Anaphase Promoting Complex. Mol. Cell Biol. 20, 242-248.
18. Labib, K., Tercero, J.A., and Diffley, J.F.X. (2000). Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288, 1643-1647.
19. Noton, E.A., and Diffley, J.F.X. (2000). CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol. Cell 5, 85-95.
20. Seki, T., and Diffley, J.F.X. (2000). Stepwise Assembly of Initiation Proteins at Budding Yeast Replication Origins in vitro. Proc. Natl. Acad. Sci. USA 97, 14115-14120.
21. Tercero, J.A., Labib, K., and Diffley, J.F.X. (2000). DNA synthesis at individual replication forks requires the essential initiation factor, Cdc45p. EMBO J. 19, 2082-2093.
22. Alcasabas, A.A., Osborn, A.J., Bachant, J., Hu, F., Werler, P.J., Bousset, K., Furuya, K., Diffley, J.F.X., Carr, A.M., and Elledge, S.J. (2001). Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat. Cell Biol. 3, 958-965.
23. Diffley, J.F.X. (2001). DNA Replication: Building the perfect switch. Curr. Biol. 11, R367-R370.
24. Labib, K., and Diffley, J.F.X. (2001). Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Curr Opin Genet Dev 11, 64-70.
25. Labib, K., Kearsey, S.E., and Diffley, J.F.X. (2001). MCM2-7 proteins are essential components of prereplicative complexes, that accumulate co-operatively in the nucleus during G1-phase, and are required to establish, but not maintain, the S-phase checkpoint. Mol. Biol. Cell. 12, 3658-3667.
26. Perkins, G., Drury, L.S., and Diffley, J.F.X. (2001). Separate SCFCDC4 recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J. 20, 4836-4845.
27. Schepers, A., and Diffley, J.F.X. (2001). Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. J Mol Biol 308, 597-608.
28. Schepers, A., Ritzi, M., Bousset, K., Kremmer, E., Yates, J.L., Harwood, J., Diffley, J.F.X., and Hammerschmidt, W. (2001). Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. EMBO J 20, 4588-4602.
29. Tercero, J.A., and Diffley, J.F.X. (2001). Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412, 553-557.
30. Diffley, J.F.X., and Labib, K. (2002). The chromosome replication cycle. J Cell Sci 115, 869-872.
31. Tanaka, S., and Diffley, J.F.X. (2002). Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 4, 198-207.
32. Tanaka, S., and Diffley, J.F.X. (2002). Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev 16, 2639-2649.
33. Tercero, J.A., Longhese, M.P., and Diffley, J.F.X. (2003). A Central Role for DNA Replication Forks in Checkpoint Activation and Response. Mol. Cell 11, 1323-1336.
34. Vernis, L., Piskur, J., and Diffley, J.F. X. (2003). Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res 31, e120.
35. Zegerman, P., and Diffley, J.F.X. (2003). Lessons in how to hold a fork. Nat Struct Biol 10, 778-779.
36. Diffley, J.F.X. (2004). Regulation of early events in chromosome replication. Curr. Biol. 14, R778-R786
37. Early, A., Drury, L.S., and Diffley, J.F. X. (2004). Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philos Trans R Soc Lond B Biol Sci 359, 31-38.
38. Merrick, C.J., Jackson, D., and Diffley, J.F. X. (2004). Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 279, 20067-20075.
39. Wang, X., Ira, G., Tercero, J.A., Holmes, A.M., Diffley, J.F.X., and Haber, J.E. (2004). Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol 24, 6891-6899.
40. Mimura, S., Seki, T., Tanaka, S., and Diffley, J. F. X. (2004). Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431, 1118-1123. 41. Mailand, N., and Diffley, J. F. X. (2005). CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C–dependent proteolysis. Cell 122, 915-926.
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