Stephen C. West
Address:
Cancer Research UK
London Research Institute
Clare Hall Laboratories
South Mimms
Herts. EN6 3LD
U.K. E-mail: stephen.west@cancer.org.uk
Website: http://science.cancerresearchuk.org/sci/genrecombi/
Telephone:
44-1707-625868 (FAX 44-1707-625803)
Date of Birth: April 11, 1952 Place of Birth: Hessle, Yorkshire, England
Educational Background: 1971 - 1974 B. Sc. in Biochemistry, Newcastle University 1974 - 1977 Ph. D. in Biochemistry, Newcastle University
Professional Experience: 2006 - present associate Director, Clare Hall Laboratories, London Research Institute, Cancer Research UK 1989 - present Senior Group Leader, Cancer Research UK (formerly Imperial Cancer Research Fund) 1997 - present Honorary Professor, University College, London 1985 - 1989 Senior Scientist, ICRF 1983 - 1985 Research Scientist, Department of Therapeutic Radiology, Yale University USA. 1978 - 1983 Post-doctoral Research Associate, Department of Molecular Biophysics and Biochemistry, and Therapeutic Radiology, Yale University USA. 1977 - 1978 Post-doctoral Research Associate, University of Newcastle.
Academic Distinctions: 2000 Elected Fellow of the Academy of Medical Sciences 2000 Elected as Member of the Academia Europaea 1995 Elected as Fellow of the Royal Society 1994 Elected as Member of EMBO
Prizes: 2009 Swiss Bridge Prize Award for Cancer Research 2008 Novartis Medal and Prize of the Biochemical Society 2007 Louis-Jeantet Prize for Medicine 2002 Leeuwenhoek Prize of the Royal Society 2001 Swiss Bridge Prize Award for Cancer Research
Honours, Awards, Special Lectures: 2009 Keynote Lecture, Keystone Conference on Telomere Biology and DNA Repair, Ashmore, Australia 2008 Novartis Prize Lecture, Cambridge 2008 Mendel Lecture, Brno, Czech Republic 2008 Keynote Lecture, ABCAM Conference on Genome Instability and Cancer, Puerto Vallarta, Mexico 2007 Keynote Lecture, Genes and Cancer Conference, Warwick, UK 2007 Opening lecture, EMBO World Conference on meiosis, Shonan, Japan 2007 Keynote lecture, ELSO Conference, Dresden, Germany 2007 Keynote lecture, UKEMS Conference, Cardiff, Wales 2007 Dean's Lecture in memory of Eugenia Spanopolou, Mount Sinai School of Medicine, New York 2007 Paul Marks Distinguished Lecture in Cancer Biology, Sloan-Kettering Cancer Institute, New York 2007 Keynote lecture, E.G. Jung 75th Anniversary Symposium, Mannheim, Germany 2005 Keynote Lecture, NIEHS Genotype to Phenotype meeting, Portland 2005 Leonard Tolmach Memorial Lecture, Washington Univ, St Louis 2005 Keynote Lecture, Royal Society of Chemistry meeting, Brighton 2005 Distinguished Lecture, Lawrence Berkeley Labs 2005 Director's Series Lecture, NIH, Bethesda 2004 Special Lecture, Skirball Symposium, New York 2005 - 2009 EU FP6 DNA Repair Consortium Award (ø445,000) 2005 - 2007 Breast Cancer Campaign Award (£98,232) 2004 Keynote Lecture, Dutch Nucleic Acid Society, Lunteren 2004 Keynote Lecture, AACR meeting, Dana Point, California 2004 Keynote Lecture, EEMS Conference, Aberdeen 2003 - 2005 Breast Cancer Campaign Award (£99,204) 2003 Invited speaker at all three meetings celebrating the 50th Anniversary of the DNA Double Helix (New York, London, Melbourne) 2002 Keynote Lecture, AACR meeting, San Francisco 2002 Keynote Lecture, Radiation Research Society meeting, Reno 2002 Leeuwenhoek Prize Lecture, The Royal Society (lecture presented in London, Nottingham and Oxford) 2001 Swiss Bridge Award for Cancer Research (£100,000) 2000 Elected as a Fellow of the Academy of Medical Sciences 2000 Elected as a Member of Academia Europaea 1999 Keynote Lecture, Keystone Symposium on DNA Replication and Recombination 1997 - 2000 Human Frontiers Science Program Award ($233,332) 1996 - 1998 Chairman, Royal Society Sectional Committee 7 1995 - 1998 Member, Royal Society Sectional Committee 7 1995 - 1997 Member, Royal Society Hooke Committee 1995 Elected as a Fellow of the Royal Society 1994 Elected as a member of EMBO 1991 - 1994 Member of the Science and Engineering Research Council, Molecular Biology and Genetics grants committee
Editorial Boards 2001 - present Editorial Board of DNA Repair 1996 - present Editorial Board of EMBO Journal 2000 - present Editorial Board of EMBO Reports 1995 - 1999 Editorial Board of Nucleic Acids Research 1996 - 1998 Associate Editor of Genes to Cells
Advisory Boards 2009 External Review Committee, Fritz Lippmann Institute, Jena, Germany 2009 - present On-Q-ity Inc, Boston 2006 - 2009 Scientific Advisory Board, DNA Repair Inc, Boston 2004 External Review Committee, Fritz Lippmann Institute, Jena, Germany 2003 External Review Committee, Centre for Biomedical Genetics, Netherlands 1998 - 2004 External Advisory Board, University of Texas Health Sciences Center, San Antonio
Meeting Organisation 1992 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 1994 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 1994 Royal Society Discussion Meeting on 'DNA Repair and (with Tomas Lindahl) 1996 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 1996 Keystone Symposium on "Mechanisms of DNA Replication and Recombination', Taos, New Mexico, USA (with Mike OøDonnell) 1998 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 1999 Juan-March Symposium on Genetic Recombination and Genome Rearrangements, Madrid, Spain 2000 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 2002 Symposium on Genome Instability, AACR meeting, San Francisco 2002 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 2003 Royal Society Discussion meeting to celebrate the 50th Anniversary of the DNA Double Helix (with David Sherratt) 2003 Joint Cancer Research UK/Sloan Kettering Cancer Institute Meeting, London (with Dale Wigley and Ken Marians) 2004 Juan March Workshop on Recombinational repair and its Links to DNA Replication and Chromosome Maintenance, Madrid 2004 EMBO Recombination Workshop, Seillac, France (with Alain Nicolas) 2004 Juan March Workshop on Genetic Recombination, Madrid (with Juan Alonso, Juan Aguilera and Steve Kowalczykowski) 2005 Joint Cancer Research UK/Sloan Kettering Cancer Institute Meeting, London (with Dale Wigley and Ken Marians) 2005 Symposium on Genome Instability, Environmental Mutagenesis meeting, San Francisco (with Jim Haber) 2006 EMBO Conference on Recombination and Genome Stability, Seillac, France (with Alain Nicolas and Marco Foiani) 2008 EMBO Conference on Recombination and Genome Stability, Il Ciocco, Italy (with Marco Foiani, Alain Nicolas and Andres Aguilera) 2009 ICGEB workshop on Proteomics, Trieste, Italy (with Alessandro Vindigni and Michael Karas) 2009 Joint Cancer Research UK/Sloan Kettering Cancer Institute Meeting, London (with Dale Wigley and Ken Marians) 2009 Inaugural Annual EMBO Conference, Amsterdam, Netherlands (with Hans Clevers)
Meeting chairman 1995 Session chairman, FASEB meeting on Genetic Recombination and Genome Rearrangements, Snowmass, Colorado, USA 1996 Session chairman, Keystone meeting on DNA replication and Recombination, New Mexico, USA 1996 Session chairman, EMBO workshop on Genetic Recombination, France 1996 Session chairman, IMP Symposium, Vienna, Austria 1996 Session chairman, Gordon Conference on DNA Repair, New Hampshire, USA 1996 Session chairman, INSERM meeting on V(D)J recombination, Aix-les-Bains, France 1998 Session chairman, EMBO workshop on Genetic Recombination, Seillac, France 1998 Session chairman, Gordon conference on Mutagenesis, New Hampshire, USA 1999 Session chairman, FASEB meeting on Genetic Recombination and Genome Rearrangements, Snowmass, Colorado, USA 2000 Session chairman, Gordon conference on Mutagenesis, Oxford 2000 Session chairman, IUBMB Symposium on DNA Enzymes, Bangalore, India 2004 Session chairman, Juan March meeting, Madrid 2005 Chairman & discussion leader, Gordon Research Conference on DNA repair, Ventura, USA 2005 Session chairman, EEMS meeting, San Francisco, USA 2005 Session chairman, joint Sloan-Kettering ø Cancer Research UK meeting, New York, USA 2005 Session chairman, Benzon Symposium, Copenhagen 2005 Session chairman, Royal Society of Chemistry meeting, Brighton 2006 Session chairman, Erling Seeberg symposium on DNA repair, Lofoten, Norway 2006 Session chairman, Recombinational Repair Meeting, Baeza, Spain 2007 Session chairman, FASEB meeting on Genetic Recombination and Genome Rearrangements, Snowmass, Colorado, USA 2008 Session chairman, Keystone meeting on DNA Replication and recombination, Santa Fe, New Mexico, USA 2009 Session chairman, GRC conference on Mammalian DNA Repair, Ventura, California, USA 2009 Session chairman, The EMBO meeting, Amsterdam, Netherlands
Societies Fellow of the Royal Society Fellow of the Academy of Medical Sciences Member of the European Molecular Biology Organisation Member of the Genetics Society Member of the Academia Europaea Cancer Research UK Committees (2000-2006) 2005 - present Member of the LRI Institute Management Committee 2004 - 2008 Member of the LRI Faculty Committee 1995 - 2006 Graduate Student Advisor (Clare Hall) 2001 - 2003 Member of the Pontecorvo Prize Committee 2003 Member of the LRI Special Seminar Committee
PUBLICATIONS AHEL, D., HOREJSI, Z., WIECHENS, N., POLO, S.E., GARCIA-WILSON, E., AHEL, I., FLYNN, H., SKEHEL, M., WEST, S.C., JACKSON, S.P. OWEN-HUGHES, T. and BOULTON, S.J. (2009). Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 325, 1240-1243. POULET, A., BUISSON, R., FAIVRE-MOSKALENKO, C., KOELBLEN, M., AMIARD, S., MONTEL, F., CUESTA-LOPEZ, S., BORNET, O., GUERLESQUIN, F., GODET, T., MOUKHTAR, J., ARGOUL, F., DECLAIS, A.-C., LILLEY, D.M.J., IP, S.C.Y., WEST, S.C., GILSON, E. and GIRAUD-PANIS, M.-J. (2009). TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J. 28, 641-651. WEST, S.C. (2009). The search for a human Holliday junction resolvase. Biochem. Soc. Trans. 37, 519-526. RASS, U., AHEL, I. and WEST, S.C. (2008) Molecular mechanism of deadenylation by the neurological disease protein Aprataxin. J. Biol. Chem. 283, 33994-34001. IP, S.C.Y., RASS, U., BLANCO, M.G., FLYNN, H.R., SKEHEL, J.M. and WEST, S.C. (2008) Identification of Holliday junction resolvases from humans and yeast. Nature, 456, 357-361. COLLIS, S.J., CICCIA, A., DEANS, A.J., HOREJSI, Z., MARTIN, J.S., MASLEN, S.L., SKEHEL, J.M., ELLEDGE, S.J., WEST, S.C. and BOULTON, S.J. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signalling independently of the Fanconi anemia core complex. Mol. Cell 32, 313-324 LIU, Y. and WEST, S.C. (2008) More complexity to the Bloom's syndrome complex. Genes & Dev., 22, 2737-2742. BARBER, L.J., YOUDS, J.L., WARD, J.D., McILWRAITH, M.J., O'NEIL, N.J., PETALCORIN, M.I.A., MARTIN, J.S., COLLIS, S.J., CANTOR, S.B., AUCLAIR, M., TISSENBAUM, H., WEST, S.C., ROSE, A.M. and BOULTON, S.J. (2008) RTEL maintains genomic stability by suppressing homologous recombination. Cell 135, 261-271. CICCIA. A. and WEST, S.C. (2008) Structural and functional relationships of the XPF/MUS81 family of proteins. Ann. Rev. Biochem, 77, 259-287. RICHARD, D.J., BOLDERSON, E., CUBEDDU, L., WADSWORTH, R.I.M., SAVAGE, K., SHARMA, K., SHARMA, G.G., NICOLETTE, M.L., TSVETANOV, S., MCILWRAITH, M., PANDITA, R., TAKEDA, S., HAY, R.T., GAUTIER, J., WEST, S.C., PAULL, T.T., PANDITA, T.K., WHITE, M.F. and KHANNA, K.K. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453, 677-681. McILWRAITH, M.J. and WEST, S.C. (2008) DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair . Molec. Cell 29, 510-516. AHEL, I., AHEL, D., MATSUSAKA, T., CLARK, A.J., PINES, J., BOULTON, S.J. and WEST, S.C. (2008) Poly(ADP-ribose)-binding zinc finger motif in DNA repair/checkpoint proteins. Nature 451, 81-85. THORSLUND, T. and WEST, S.C. (2007) BRCA2: A universal recombinase regulator. Oncogene 26, 7720-7730. AHEL, I., RASS, I. and WEST, S.C. (2007) DNA repair defects and neurodegenerative disease. Cell, 130, 991-1004. STEWART, G.S., STANKOVIC, T., BYRD, P.J., WECHSLER, T., MILLER, E.S., HUISSOON, A., DRAYSON, M., WEST, S.C., ELLEDGE, S.J. AND TAYLOR, A.M.R. (2007) RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signalling. Proc. Natl. Acad. Sci. U.S.A. 104, 16910-16915. ESASHI, F., GALKIN, V.E., YU, X., EGELMAN, E.H. and WEST, S.C. (2007) Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nature Structural and Molecular Biology 14, 468-474. THORSLUND, T., ESASHI, F., and WEST, S.C. (2007) Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J. 26, 2915-2922. CICCIA, A., LING, C., COULTHARD, R., YAN, Z., XUE, Y., MEETEI, A.R., LAGHMANI, E.H., JOENJE, H., McDONALD, N., DE WINTER, J.P., WANG, W. and WEST, S.C. (2007) Identification of FAAP24, a novel Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell, 25, 331-343. LIU, Y., TARSOUNAS, M., OøREGAN, P. and WEST, S.C. (2007) Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J. Biol. Chem, 282, 1973-1979. RASS, U., AHEL, I. and WEST, S.C. (2007) Actions of Aprataxin in multiple DNA repair pathways. J. Biol. Chem., 282, 9469-9474. KUZNETZOV, S., FERNANDEZ-CAPETILLO, O., SHUDA, A., MARTIN, B.K., SOUTHON, E., TESSAROLLO, L., DONOVAN, P.J., LIU, Y., NUSSENZWEIG, A., WEST, S.C. and SHARAN, S.K. (2007) RAD51C is required for meiotic chromosome segregation in mice. J. Cell. Biol., 176, 581-592. AHEL, I., RASS., U, EL-KHAMISY, S.F., KATYAL, S., CLEMENTS, P.M., MCKINNON, P.J., CALDECOTT, K.W. and WEST, S.C. (2006) Aprataxin, defective in the neurodegenerative disease ataxia oculomotor apraxia, resolves abortive DNA ligation intermediates. Nature, 443, 713-716. RASS, U. and WEST, S.C. (2006) Synthetic junctions as tools to identify and characterise Holliday junction resolvases. In Meth. Enzymol. Ed. Campbell, J.L., and Modrich, P. Academic Press, San Diego. Vol 408, p485-501 . RODRIGUE, A., LAFRANCE, M., GAUTHIER, M.-C., MCDONALD, D., HENDZEL, M., WEST, S.C., JASIN, M. and MASSON, J.-Y. (2006) Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J., 25, 222-231. McILWRAITH, M.J., VAISMAN, A., LIU, Y., FANNING, E., WOODGATE, R. and WEST, S.C. (2005) Human DNA polymerase h promotes DNA synthesis from strand invasion intermediates of homologous recombination. Molec. Cell 20, 783-792. ESASHI, F., CHRIST, N, GANNON, J., LIU, Y., HUNT, T., JASIN, M. and WEST, S.C. (2005) CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434, 598-604. TARSOUNAS, M. and WEST, S.C. (2005) Recombination at mammalian telomeres. Cell Cycle 4, 33-35. GALKIN, V.E., ESASHI, F., YU, X., YANG, S., WEST, S.C. and EGELMAN, E.H. (2005) BRCA2 BRC motifs bind RAD51-DNA filaments. Proc. Natl. Acad. Sci. U.S.A 102, 8537-8542. LIU, Y. and WEST, S.C. (2004) Happy Hollidays: 40th anniversary of the Holliday junction. Nat. Rev. Mol. Cell Biol. 5, 937-944. TARSOUNAS, M., MUNOZ, P., CLAAS, A., SMIRALDO, P.G., PITTMAN, D.L., BLASCO, M.A. and WEST, S.C. (2004). Telomere maintenance requires the RAD51D recombination/repair protein. Cell 117, 337-347. LIU, Y., MASSON, J.-Y. SHAH, R., OøREGAN, P. and WEST, S.C. (2004) RAD51C is required for Holliday junction processing in mammalian cells. Science 303, 243-246. GARCIA, P.L., LIU, Y., JIRICNY, J., WEST, S.C. and JANSCAK, P. (2004) Human RecQ5b, a protein with DNA helicase and strand annealing activities in a single polypeptide. EMBO J. 23, 2882-2891. SURRALES, J., JACKSON, S.P., JASIN, M., KASTAN, M.B., WEST, S.C. and JOENJE, H. (2004) Molecular cross-talk among chromosome fragility syndromes. Genes Dev., 18, 1359-1370. HUSSAIN, S., WILSON, J.B., MEDHURST, A.L., HEJNA, J., WITT, E., ANANTH, S., DAVIES, A., MASSON, J.-Y., MOSES, R., WEST, S.C., de WINTER, J.P., ASHWORTH, A., JONES, N.J. and MATHEW, C.G. (2004) Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Human Molec. Genet. 13, 1241-1248. LIU, Y., STASIAK, A.Z., MASSON, J.-Y., McILWRAITH, M.J., STASIAK, A. and WEST, S.C. (2004) Conformational changes modulate the activity of human RAD51 protein. J. Mol. Biol. 337, 817-827. CONSTANTINOU, A., and WEST, S.C. (2004). Holliday junction branch migration and resolution assays. In øMethods in Molecular Biologyø, Ed Waldman, A., Humana Press, Totowa NJ., pp 239-253. SHERRATT, D.J. and WEST, S.C. (2004). Introduction to øReplicating and Reshaping DNA: A celebration of the jubilee of the double helix. Phil. Trans. R. Soc. Lond. B. 359, 3-5. TARSOUNAS, M., DAVIES, A.A. and WEST, S.C. (2004). RAD51 localization and activation following DNA damage. Phil. Trans. R. Soc. Lond. B. 359, 87-93 ABRAHAM, J., LEMMERS, B., HANDE, M.P., MOYNAHAN, M.E., CHAHWAN, C., CICCIA, A., ESSERS, J., HANADA, K., CHAHWAN, R., KHAW, A.K., McPHERSON, P., SHAHABELDIN, A., LAISTER, R., ARROWSMITH, C., KANAAR, R., WEST, S.C., JASIN, M., and HAKEM, R. (2003). EME1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 22, 6137-6147. CICCIA, A., CONSTANTINOU, A., and WEST, S.C. (2003). Identification and characterization of the human MUS81/EME1 endonuclease. J. Biol. Chem. 278, 25172-25178. WEST, S.C. (2003). Molecular views of recombination and its control. Nat. Rev. Mol. Cell Biol. 4, 435-445. DAI, Y., KYSELA, B., HANAKAHI, L.A., MANOLIS, K.G., RIBALLO, E., STUMM, M., HARVILLE, T.O., WEST, S.C., OETTINGER, M.A. and JEGGO, P.A. (2003). Non-homologous end-joining and V(D)J recombination require an additional novel factor. Proc. Natl. Acad. Sci. USA., 100, 2462-2467. HENRY-MOWATT, J., JACKSON, D., MASSON, J.Y., JOHNSON, P.A., CLEMENTS, P.M., BENSON, F.E., THOMPSON, L.H., TAKEDA, S., WEST, S.C. and CALDECOTT, K.W. (2003). XRCC3 and RAD51 modulate replication fork progression on damaged vertebrate chromosomes. Molec. Cell, 11, 1109-1117. TARSOUNAS, M., DAVIES, D. and WEST, S.C. (2003). BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 22, 1115-1123. WEST, S.C. (2002). Cross-links between Fanconi anemia and BRCA2. DNA Repair, 2, 231-234. CONSTANTINOU, A., CHEN, X.-B., McGOWAN, C.H. and WEST, S.C. (2002) Holliday junction resolution in human cells: Two junction endonucleases with distinct substrate specificities. EMBO J. 21, 5577-5585. SINGLETON, M.R., WENTZELL, L.M., LIU, Y., WEST, S.C. and WIGLEY, D.B. (2002). Structure of the single-strand annealing domain of human RAD52 protein. Proc. Natl. Acad. Sci. USA. 99, 13492-13497. FRENCH, C.A., MASSON, J.-Y., GRIFFIN, C.S., OøREGAN, P., WEST, S.C. and THACKER, J. (2002). Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J. Biol. Chem. 277, 19322-19330. HANAKAHI, L.A. and WEST, S.C. (2002). Specific interaction of IP6 with human Ku70/80, the DNA binding subunit of DNA-PK. EMBO J. 21, 2038-2044. CHAPPELL, C., HANAKAHI, L.A., WEINFELD, M. and WEST, S.C. (2002). Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J. 21, 2827-2832. LIU, Y. and WEST, S.C. (2002). Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res. 4, 9-13. MASSON, J.-Y., TARSOUNAS, M.C., STASIAK, A.Z., STASIAK, A., SHAH, R., MCILWRAITH, M.J., BENSON, F.E. and WEST, S.C. (2001). Identification and purification of two distinct complexes containing the five RAD51 paralogues. Genes & Dev. 15, 3296-3307. MCILWRAITH, M.J., HALL, D.R., STASIAK, A.Z., STASIAK, A., WIGLEY, D.B. and WEST, S.C. (2001). RadA protein from Archeoglobus fulgidansforms rings, nucleoprotein filaments and catalyses homologous recombination. Nucl. Acids Res. 29, 4509-4517. VAN DYCK, E., STASIAK, A.Z., STASIAK, A. and WEST, S.C. (2001). Visualisation of recombination intermediates produced by RAD52-mediated single-strand annealing. EMBO Rep. 2, 905-909. MASSON, J.-Y., STASIAK, A.Z., STASIAK, A., BENSON, F.E. and WEST, S.C. (2001). Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Proc. Natl. Acad. Sci. U.S.A. 98, 8440-8446. YU, X., JACOBS, S.A., WEST, S.C., OGAWA, T. and EGELMAN, E.H. (2001). Domain structure and dynamics in the helical filaments formed by RecA and RAD51 on DNA. Proc. Natl. Acad. Sci. U.S.A. 98, 8419-8424. CONSTANTINOU, A., DAVIES, A.A. and WEST, S.C. (2001). Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells. Cell 104, 259-268. DAVIES, A.A., MASSON, J.Y., MCILWRIATH, M.J., STASIAK, A.Z., STASIAK, A., VENKITARAMAN, A.R. WEST, S.C. (2001). Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Molec. Cell. 7, 273-282. MASSON, J.-Y. and WEST, S.C. (2001) The RAD51 and DMC1 recombinases; A non-identical twin relationship. Trends Biochem. Sci. 26, 138-143. MCILWRAITH, M and WEST S.C. (2001) The efficiency of strand invasion by Escherichia coli RecA is dependent upon the length and polarity of ssDNA tail. J. Mol. Biol. 305, 23-31. HANAKAHI, L.A., BARTLET-JONES, C.CHAPPELL, PAPPIN, D. and WEST, S.C. (2000). Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell 102, 721-729. PARSONS, C.A., BAUMANN, P., VAN DYCK, E., and WEST, S.C. (2000) Precise binding of single-stranded DNA termini by human RAD52 protein. EMBO J. 19, 4175-4181. WEST, S.C., CHAPPELL, L., HANAKAHI, L.A., MASSOM, J.Y., McILWRAITH, M. and VAN DYCK, E. (2000). Double-strand break repair in human cells. Cold. Spring Harbor Symp. Quant. Biol. 65, 315-321. Arenas-Licea, J., van Gool, A.J., Keeley, A.J., Davies, A., WEST, S.C. and TSANEVA, I.R. (2000) Functional interactions of Mycobacterium leprae RuvA with Escherichia coli RuvB and RuvC on Holliday junctions. J. Mol. Biol. 301, 839-850. YU, V.P.C.C., KÖEHLER, M., STEINLEIN, C., SCHMID, M., HANAKAHI, L.A., VAN GOOL, A.J., WEST, S.C. and VENKITARAMAN, A.R. (2000) Gross chromosomal rearrangements and genetic exchange between non-homologous chromosomes following BRCA2 inactivation. Genes & Dev. 14, 1400-1406. KAROW, J.K., CONSTANTINOU, A., LI, J.-L., WEST, S.C. and HICKSON, I.D. (2000) The Bloom's Syndrome gene product promotes branch migration of Holliday junctions. Proc. Natl. Acad. Sci. U.S.A. 97, 6504-6508. CONSTANTINOU, A., TARSOUNAS, M. KAROW, J.K., BROSH, R.M., BOHR, V.A., HICKSON, I.D. and WEST, S.C. (2000) ATP-dependent translocation of Holliday junctions by the Werner Syndrome protein. EMBO Rep. 1, 80-84. McILWRAITH, M.J. VAN DYCK, E., MASSON, J.Y., STASIAK, A.Z., STASIAK, A. and WEST, S.C. (2000) Reconstitution of the strand invasion step of double-strand break repair using human RAD51, RAD52 and RPA proteins. J. Mol. Biol. 304, 151-164. EGGLESTON, A.K. and WEST, S.C. (2000) Cleavage of Holliday junctions by the E. coli RuvABC complex. J. Biol. Chem. 275, 26467-26476. STASIAK, A.Z., LARQUET, E., STASIAK, A., MÜLLER, S., ENGEL, A., VAN DYCK, E., WEST, S.C. and EGELMAN, E.H. (2000) The human RAD52 protein exists as a helptameric ring, with structural homology to hexameric helicases. Curr. Biol. 10, 337-340. GEORGE, H., KURAOKA, I., NAUMAN, D.A., KOBERTZ, W.R., WOOD, R.D. and WEST, S.C. (2000) RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer. Curr. Biol. 10, 103-106. PASSY, S.I., YU, X., LI, Z., RADDING, C.M., MASSON, J.-Y., WEST, S.C. and EGELMAN, E.H. (1999) Human DMC1 protein binds DNA as an octameric ring. Proc. Natl. Acad. Sci. USA 96, 10684-10688. MASSON, J.-Y., DAVIES, A.A., HAJIBAGHERI, N.M.A., VAN DYCK, E., BENSON, F.E., STASIAK, A.Z., STASIAK, A. and WEST, S.C. (1999) The meiosis-specific recombinase hDMC1 forms ring structures and interacts with hRAD51. EMBO J.18, 6552-6560. GEORGE, H., MÉZARD, C., STASIAK, A., and WEST, S.C. (1999) Helicase-defective RuvBD113E promotes RuvAB-mediated branch migration in vitro. J. Mol. Biol. 293, 505-519. BAUMANN, P. and WEST, S.C. (1999) Heteroduplex formation by human RAD51 protein: Effects of DNA end-structure, hRP-A and hRAD52. J. Mol. Biol. 291, 363-374. VAN GOOL, A.J., HAJIBAGHERI, N.M.A., STASIAK, A. and WEST, S.C. (1999) Assembly of the E. coli RuvABC resolvasome directs the orientation of Holliday junction resolution. Genes & Dev. 13, 1861-1870. VAN DYCK, E., STASIAK, A.Z., STASIAK, A. and WEST, S.C. (1999) Binding of double-strand breaks in DNA by human RAD52 protein. Nature, 398, 728-731. MÉZARD, C., GEORGE, H., DAVIES, A.A., VAN GOOL, A.J., ZERBIB, D., STASIAK, A. and WEST, S.C. (1999) E. coli RuvBL268S: A mutant RuvB protein that exhibits wild-type activities in vitro but confers a UV-sensitive ruvphenotype in vivo. Nucl. Acids Res. 27, 1275-1282. BAUMANN, P. and WEST, S.C. (1998) DNA end-joining catalyzed by human cell-free extracts. Proc. Natl. Acad. Sci. USA., 95, 14066-14070. VAN DYCK, E., HAJIBAGHERI, N.M.A., STASIAK, A. and WEST, S.C. (1998) Visualization of human RAD52 protein and its complexes with hRAD51 and DNA. J. Mol. Biol. 284, 1027-1038. WEST, S.C. (1998). RuvA gets X-rayed on Holliday. Cell, 94, 699-701. ZERBIB, D., MÉZARD, C., GEORGE, H. and WEST, S.C. (1998) Coordinated actions of RuvABC in Holliday junction processing. J. Mol. Biol. 281, 621-630. DAVIES, A.A. and WEST, S.C. (1998) Formation of RuvABC-Holliday junction complexes in vitro. Curr. Biol. 8, 725-727. HAGAN, N.F.P., VINCENT, S.D., INGLESTON, S.M., SHARPLES, G.J., BENNETT, R.J., WEST, S.C. and LLOYD, R.G. (1998) Sequence-specificity of Holliday junction resolution: Identification of RuvC mutants defective in metal binding and target site recognition. J. Mol. Biol. 281, 17-29. BAUMANN, P. and WEST, S.C. (1998) Human RAD51 protein: Role in homologous recombination and double-strand break repair. Trends Bio. Sci. 23, 247-251. Van GOOL, A.J., SHAH, R., MÉZARD, C. and WEST, S.C. (1998) Functional interactions between the Holliday junction resolvase and the branch migration motor of E. coli. EMBO J. 17, 1838-1845. BENSON, F.E., BAUMANN, P. and WEST, S.C. (1998) Synergistic actions of RAD51 and RAD52 in recombination and DNA repair. Nature 391, 401-404. EGGLESTON, A.K. and WEST, S.C. (1997) Recombination initiation: Easy as A, B, C, D... c? Curr. Biol. 7, 745-749. WEST, S.C. (1997) Processing of recombination intermediates by the RuvABC proteins. Ann. Rev. Genetics. 31, 213-244.MÉZARD, C., DAVIES, A.A., STASIAK, A. and WEST, S.C. (1997) Biochemical properties of RuvBD113N: A mutation in helicase motif II of the RuvB hexamer affects DNA binding and ATPase activities. J. Mol. Biol. 271, 704-717. ZERBIB, D., COLLOMS, S.D., SHERRATT, D.J. and WEST, S.C. (1997) Effect of DNA topology on Holliday junction resolution by Escherichia coli RuvC and bacteriophage T7 endonuclease I. J. Mol. Biol. 270, 663-673. BAUMANN, P. and WEST, S.C. (1997) The human RAD51 protein: polarity of strand transfer and stimulation by hRP-A. EMBO J. 16, 5198-5206. BARLOW, A.L., BENSON, F.E., WEST, S.C. and HULTÉN, M.A. (1997) Distribution of the RAD51 recombinase in human and mouse spermatocytes. EMBO J. 16, 5207-5215. BAUMANN, P., BENSON, F.E., HAJIBAGHERI, N. and WEST, S.C. (1997) Purification of human RAD51 protein by selective spermidine precipitation. Mutat. Res. 384, 65-72. EGGLESTON, A.K., MITCHELL, A.H. and WEST, S.C. (1997) In vitroreconstitution of the late steps of genetic recombination in E. coli. Cell, 89, 607-617. SHAH, R., COSSTICK, R. and WEST, S.C. (1997) The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts. EMBO J. 16, 1464-1472. YU, X., WEST, S.C. and EGELMAN, E.H. (1997) Structure and subunit composition of the RuvAB-Holliday junction complex. J. Mol. Biol. 266, 217-222. STASIAK, A., WEST, S.C. and EGELMAN, E.H. (1997) Sickle cell anamia research and a recombinant DNA technique. Science 277, 460-462. BAUMANN, P., BENSON, F. E., and WEST, S. C. (1996). Human RAD51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell, 87, 757-766. WEST, S.C. (1996) DNA helicases: New breeds of translocating motors and molecular pumps. Cell, 86, 177-180. WEST, S.C. (1996) DNA helicases get physical. Nature 384, 316-317. HIOM, K., TSANEVA, I.R. and WEST, S.C. (1996). The directionality of RuvAB-mediated branch migration: In vitro studies with three-armed junctions. Genes to Cells, 1, 443-451. MITCHELL, A.H. and WEST, S.C. (1996) Role of RuvA in branch migration reactions catalyzed by the RuvA and RuvB proteins of Escherichia coli. J. Biol. Chem. 271, 19497-19502. BENNETT, R.J. and WEST. S.C. (1996) Resolution of Holliday junctions in genetic recombination: RuvC protein nicks DNA at the point of strand exchange. Proc. Natl. Acad. Sci. U.S.A. 93, 12217-12222. ADAMS, D.E. and WEST, S.C. (1996) Bypass of DNA heterologies during RuvAB-mediated three- and four-strand branch migration.J. Mol. Biol. 263, 582-596. EGGLESTON, A. K., and WEST, S. C. (1996). Exchanging partners: Recombination in E. coli. Trends in Genetics, 12, 20-26. WEST, S. C. (1996). The RuvABC Proteins and Holliday junction processing in Escherichia coli. J. Bacteriol., 178, 1237-1241 PARSONS, C. A., STASIAK, A., and WEST, S. C. (1995). The E. coli RuvAB proteins branch migrate Holliday junctions through heterologous DNA sequences in a reaction facilitated by SSB. EMBO J., 14, 5736-55744. HIOM, K. and WEST, S.C. (1995). Characterisation of RuvAB-Holliday junction complexes by glycerol gradient centrifugation. Nucl. Acids Res. 23, 3621-3626. ADAMS, D.E. and WEST, S.C. (1995). Relaxing and unwinding on Holliday: DNA helicase-mediated branch migration. Mutat. Res. DNA Repair. 337, 149-159. DAVIES, A.A., FRIEDBERG, E.C., TOMKINSON, A.E., WOOD, R.D. and WEST, S.C. (1995). Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination. J. Biol. Chem. 270, 24638-24641. BENNETT, R. J., and WEST, S. C. (1995). Structural analysis of the RuvC-Holliday junction complex reveals an unfolded junction. J. Mol. Biol. 252, 213-226. WEST, S. C. (1995). Formation, translocation and resolution of Holliday junctions during homologous genetic recombination. In DNA Repair and Recombination, T. Lindahl and S. C. West, eds. (London: Chapman & Hall), pp. 17-21. BENNETT, R. J., and WEST, S. C. (1995). RuvC protein resolves Holliday junctions via cleavage of the continuous (non-crossed) strands. Proc. Natl. Acad. Sci. U.S.A., 92, 5635-5639. PARSONS, C. A., STASIAK, A., BENNETT, R. J., and WEST, S. C. (1995). Structure of a multisubunit complex that promotes DNA branch migration. Nature 374, 375-378. HIOM, K., and WEST, S. C. (1995). The mechanism of branch migration in homologous recombination: Assembly of a RuvAB-Holliday junction complex in vitro. Cell, 80, 787-793. ADAMS, D. E., and WEST, S. C. (1995). Unwinding of closed circular DNA by the Escherichia coli RuvA and RuvB recombination/repair proteins. J. Mol. Biol., 247, 404-417. WEST, S. C. (1995). Cleavage of Holliday junctions by Rad1? Nature373, 27-28. WEST, S. C. (1995). Formation, translocation and resolution of Holliday junctions during homologous genetic recombination. Phil. Trans. Royal. Soc. Part B. 347, 21-252. SHAH, R., BENNETT, R. J. and WEST, S. C. (1994). Genetic recombination in Escherichia coli: RuvC protein cleaves Holliday junctions at resolution hotspots in vitro. Cell 79, 853-864. ADAMS, D. E., TSANEVA, I. R. and WEST, S. C. (1994). Dissociation of RecA filaments from duplex DNA by the RuvA and RuvB DNA repair proteins. Proc. Natl. Acad. Sci. U.S.A. 91, 9901-9905. O'DONOVAN, A., DAVIES, A.A., MOGGS, J.G., WEST, S.C. and WOOD, R.D. (1994). XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair. Nature 371, 432-435. BENSON, F. E., STASIAK, A. and WEST, S. C. (1994). Purification and characterization of the human RAD51 protein, an analogue of Escherichia coli RecA. EMBO J. 13, 5764-5771. MITCHELL, A. H. and WEST, S. C. (1994). Hexameric rings of Escherichia coli RuvB protein: Cooperative assembly, processivity, and ATPase activity. J. Mol. Biol. 243, 208-215. TSANEVA, I. R. and WEST, S. C. (1994). Targeted versus non-targeted DNA helicase activity of the RuvA and RuvB proteins of Escherichia coli. J. Biol. Chem. 269, 26552-26558. STASIAK, A., TSANEVA, I. R., WEST, S. C., BENSON, C. J. B., YU, X. and EGELMAN, E. H. (1994). The Escherichia coliRuvB branch migration protein forms double hexameric rings around DNA. Proc. Natl. Acad. Sci. U.S.A. 91, 7618-7622. WEST, S.C. (1994). Processing of Holliday junctions by RuvABC ø An overview. In DNA Damage, Ed. Wallace, S.S., Van Houten, B. and Kow, Y.K. Annals of the New York Academy of Sciences, Vol 726, pp 156-164, New York. SHAH, R., BENNETT, R. J. and WEST, S. C. (1994). Activation of RuvC Holliday junction resolvase in vitro . Nucl. Acids Res . 22, 2490-2497. WEST, S.C. (1994). The processing of recombination intermediates: Mechanistic insights from studies of bacterial proteins. Cell 76, 9-15. DUNDERDALE, H.J. and WEST, S.C. (1994). Recombination genes and proteins. Current Opinion in Genes and Development . 4, 221-228. DUNDERDALE, H., SHARPLES, G.J., LLOYD, R.G. and WEST, S.C. (1994). Cloning, overexpression, purification and characterization of the Escherichia coli RuvC Holliday junction resolvase. J. Biol. Chem. 269, 5187-5194. BENSON, F. and WEST, S.C. (1994). Substrate specificity of the Escherichia col i RuvC protein: Resolution of 3 and 4-stranded recombination intermediates. J. Biol. Chem . 269, 5195-5201. HYDE, H., DAVIES, A. and WEST, S.C. (1994). Resolution of recombination intermediates by a mammalian activity functionally analogous to Escherichia coli RuvC resolvase. J. Biol. Chem. 269, 5202-5209. MÜLLER, B. and WEST, S.C. (1994). Processing of Holliday junctions by the Escherichia coli RuvA, RuvB, RuvC and RecG proteins. Experientia 50, 216-222. MÜLLER, B. and WEST, S.C. (1994). An assay for in vitro recombination between duplex DNA molecules. In Methods in Molecular Biology: DNA-Protein Interactions: Principles and Protocols in Protein-Nucleic Acid Interactions . Ed. G.G. Neale. Humana Press. Vol 30, 413-423. WEST, S. C., TSANEVA, I. R., HIOM, K. and BENSON, F. E. (1994). Late steps in genetic recombination: Branch migration and Holliday junction resolution by RuvA, RuvB and RuvC proteins. Cold Spring Harb. Symp. Quant. Biol . 58, 525-531. BENNETT, R.J. and WEST, S.C. (1993). Cleavage of Holliday junctions by RuvC resolvase: Cleavage specificity and DNA distortion. Cell 74, 1021-1031. PARSONS, C.A. and WEST, S.C. (1993). Branch migration catalysed by the E. col i RuvA and RuvB proteins: Detection of a RuvAB-Holliday junction complex. J. Mol. Biol. 232, 397-405. MÜLLER, B., TSANEVA, I. R. and WEST, S. C. (1993). Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins: I. Comparison of the RuvAB- and RuvB-mediated reactions. J. Biol. Chem. 268, 17179-17184. MÜLLER, B., TSANEVA, I. R. and WEST, S. C. (1993). Branch migration of Holliday junctions promoted by the Escherichia coli RuvA and RuvB proteins: II. Interaction of RuvA and RuvB with DNA. J. Biol. Chem. 268, 17185-17189. TSANEVA, I.R., MÜLLER, B. and WEST, S.C. (1993). The RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro . Proc. Natl. Acad. Sci. USA . 90, 1315-1319. WEST, S.C., PARSONS, C.A., BENNETT, R.J., BENSON, F.E., CONNOLLY, B. and DUNDERDALE, H.J. (1993). Resolution of Holliday junctions by the E. coli RuvC protein. Nucl. Acids and Molecular Biology . Vol. 7. Ed. F. Eckstein and D. Lilley. Springer-Verlag. pp190-201. WEST, S.C. (1993). The nucleases of genetic recombination. Nucleases . Ed. Linn, S.M., Lloyd, R.S. and Roberts, R.J. 2nd Edition, Cold Spring Harb. Press. pp 145-170. WEST, S.C. (1992). Enzymes and molecular mechanisms of genetic recombination Annual Reviews of Biochemistry 61, 603-640. TSANEVA, I.R., MÜLLER, B., WEST, S.C. (1992). ATP-dependent branch migration of Holliday junctions promoted by the RuvA and RuvB proteins of E. coli . Cell . 69, 1171-1180. MÜLLER, B., BURDETT, I. and WEST, S.C. (1992). Unusual stability of Holliday junctions made by E. coli RecA protein. EMBO J . 11, 2685-2693. PARSONS, C.A., TSANEVA, I.R., LLOYD, R.G. and WEST, S.C. (1992). Interaction of Escherichia coli RuvA and RuvB proteins with synthetic Holliday junctions. Proc. Natl. Acad. Sci. USA . 89, 5452-5456. TSANEVA, I.R., ILLING, G.T., LLOYD, R.G. and WEST, S.C. (1992). Purification and properties of the E. coli RuvA and RuvB proteins. Molec. Gen. Genet. 235, 1-10. WEST, S.C. and CONNOLLY, B. (1992). Biological roles of the E. coli RuvA, RuvB and RuvC proteins revealed. Molecular Microbiology 6, 2755-2759. DUNDERDALE, H.J., BENSON, F.E., PARSONS, C.A., SHARPLES, G.J., LLOYD, R.G., and WEST, S.C. (1991). The formation and resolution of recombination intermediates by E. coli RecA and RuvC proteins. Nature . 354, 506-510. CONNOLLY, B., PARSONS, C.A., BENSON, F.E., DUNDERDALE, H.J., SHARPLES, G.J., LLOYD, R.G. and WEST, S.C. (1991). Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product. Proc. Natl. Acad. Sci. U.S.A . 88, 6063-6067. CONNOLLY, B. and WEST, S.C. (1991). Genetic recombination in E. coli: Holliday junctions made by RecA protein are resolved by fractionated cell-free extracts. Proc. Natl. Acad. Sci . U.S.A. 87, 8476-8480. MÜLLER, B., BOEHMER, P. EMMERSON, P., and WEST, S.C. (1991). Genetic recombination in E. coli : Action of RecBCD enzyme on Holliday structures made by RecA protein. J. Biol. Chem . 266, 19028-1903. WEST, S.C. (1991). Three-stranded DNA helices as intermediates in genetic recombination. BioEssays 13, 37-38. MÜLLER, B., JONES, A. and WEST, S.C. (1990). T7 endonuclease I resolves Holliday junctions formed in vitro by RecA protein. Nucl. Acids Res 18, 5633-5636. MÜLLER, B., JONES, C., KEMPER, B. and WEST, S.C. (1990). Enzymatic formation and resolution of Holliday structures in vitro . Cell 60, 329-336. ELBOROUGH, K. and WEST, S.C. (1990). Cleavage of synthetic Holliday junctions by an activity purified from calf thymus. EMBO J. 9, 2931-2936. CONLEY, E.C. and WEST, S.C. (1990). Underwinding of DNA associated with duplex-duplex pairing by E. coli RecA protein. J. Biol. Chem . 265, 10156-10163. PARSONS, C.A., KEMPER, B. and WEST, S.C. (1990). Interaction of a four-way junction in DNA with T4 endonuclease VII. J. Biol. Chem. 265, 9285-9289. PICKSLEY, S.M., PARSONS, C.A., KEMPER, B. and WEST, S.C. (1990). Cleavage specificity of T4 endonuclease VII and T7 endonuclease I on synthetic branch migratable Holliday junctions. J. Mol. Biol . 212, 723-735. PARSONS, C.A. and WEST, S.C. (1990). Specificity of binding to four-way junctions in DNA by T7 endonuclease I. Nucl. Acids Res 18, 4377-4384. WEST, S.C. (1990). Processing of recombination intermediates in vitro . BioEssays 12, 151-154. MÜLLER, B., JONES, A. and WEST, S.C. (1990). Resolution of Holliday junctions within RecA helical filaments. In "Ionizing Radiation Damage to DNA: Molecular Approaches " UCLA Symposia on Molecular and Cellular Biology, New Series. Eds. Wallace, S. and Painter, R. Wiley/Liss Inc., New York, NY Vol 136, pp 163-171. CONLEY, E.C., MÜLLER, B. and WEST, S.C. (1990). Molecular mechanism of post-replicational repair: Formation and resolution of recombination intermediates in vitro. In "Mutation and the Environment ", Part A: Basic mechanisms, Vol. 340A. Ed Mendelsohn, M.L. and Albertini, R.J. Wiley/Liss Inc., New York. p121-133. WEST, S.C., MÜLLER, B., CONLEY, E.C., KEMPER, B., PARSONS, C.A. and PICKSLEY, S.M. (1990). Intermediates in genetic recombination: Formation and resolution of Holliday junctions in vitro. Structure and Methods, Human Genome Initiative and DNA Recombination Vol 1. Ed Sarma R.H. and Sarma, M.H. , Adenine Press, New York. Vol 1. 193-202. CONLEY, E.C. and WEST, S.C. (1989). Homologous pairing and the formation of nascent synaptic intermediates between regions of duplex DNA by RecA protein. Cell 56, 987-995. PARSONS, C.A., MURCHIE, A.I.H., LILLEY, D.M.J. and WEST, S.C. (1989). Resolution of model Holliday junctions by yeast endonuclease: Effect of DNA structure and sequence. EMBO J . 8, 239-246. WEST, S.C. (1989). Gene manipulation - the cellular way. Review of "The Recombination of Genetic Material". Ed K. B. Low, Academic Press Inc. Trends in Genetics 5, 29-30. WEST, S.C. (1989). Pragmatism rules. Review of "Genetic Recombination". Ed R. Kucherlapati and G. R. Smith, ASM Press. Trends in Biochemical Sciences 14, 351. WEST, S.C. (1989). Resolution of model Holliday junctions in vitro. In "Nucleic Acids and Molecular Biology ," Vol 3. Ed F. Eckstein and D.M.J. Lilley. Springer-Verlag, Berlin, p44-55. WEST, S.C., ELBOROUGH, K.M., PARSONS, C.A. and PICKSLEY, S.M. (1989). Proteins from yeast and human cells specific for model Holliday junctions in DNA. In "DNA Repair Mechanisms and their Biological Implications in Mammalian Cells " Ed M. Lambert, Plenum Press, New York p233-243. PARSONS, C.A. and WEST, S.C. (1988). Resolution of model Holliday junctions by yeast endonuclease is dependent upon homologous DNA sequences. Cell 52, 621-629. ELBOROUGH, K. and WEST, S.C. (1988). Specific binding to cruciform DNA structures by a protein from human cell-free extracts. Nucl. Acids Res. 16, 3603-3614. WEST, S.C. (1988). DNA-protein interactions in genetic recombination. Trends in Genetics 4, 8-13. HAN, T.R, WEST, S.C. and HOWARD-FLANDERS, P. (1988). RecA-mediated strand exchange reactions between duplex DNA molecules containing damaged bases, deletions and insertions. J. Biol. Chem . 263, 7431-7436. ELBOROUGH, K. and WEST, S.C. (1988). Specific binding of a human protein to X- and Y-junctions in DNA. In "Mechanisms and Consequences of DNA Damage Processing " UCLA Symposium on Molecular and Cellular Biology, New Series, Vol 83. Ed. E. Friedberg and P. Hanawalt, A.R. Liss Inc., New York, p13-22. WEST, S.C., PARSONS, C.A. and PICKSLEY, S.M. (1987). Purification and properties of a nuclease from Saccharomyces cerevisiae that cleaves cruciform junctions in DNA. J. Biol. Chem. 262, 12752-12758. WEST, S.C. (1987). Specific Cleavage of cruciform DNA structures by a nuclease purified from Saccharomyces cerevisiae . In "Mechanisms of DNA Replication and Recombination " UCLA Symposium on Molecular and Cellular Biology, New Series, Vol 47, ed. T. Kelley & R. McMacken, A.R. Liss Inc., New York, p647-656 (1987). HOWARD-FLANDERS, P., WEST. S.C., CASSUTO, E., HAN, T.R. and EGELMAN, E. (1987). Structure of RecA spiral filaments and their role in homologous pairing and strand exchange in genetic recombination. In "Mechanisms of DNA Replication and Recombination " UCLA Symposium on Molecular and Cellular Biology, New Series, Vol 47, ed. T. Kelley & R. McMacken, A.R. Liss Inc., New York, p609-617. WEST, S.C. and KORNER, A. (1985). Cleavage of cruciform DNA structures by an activity purified from Saccharomyces cerevisiae . Proc. Natl. Acad. Sci. USA 82, 6445-6449. WEST, S.C. and HOWARD-FLANDERS, P. (1984). Duplex-duplex interactions catalyzed by RecA protein allow strand exchanges to pass double strand breaks in DNA. Cell 37, 683-691. HOWARD-FLANDERS, P., WEST, S.C. and STASIAK, A.J. (1984). Role of RecA spiral filaments in genetic recombination. Nature 309, 215-220. WEST, S.C. and LITTLE, J.W. (1984). P. mirabilis RecA protein catalyses cleavage of the E. coli LexA protein and the lambda repressor in vitro . Molec. Gen. Genet . 194, 111-114. HOWARD-FLANDERS, P., WEST, S.C., RUSCHE, J.R. and EGELMAN, E. (1984). Molecular mechanisms of general genetic recombination: The DNA binding sites of RecA protein. Cold Spring Harbor Symposium 49, 571-580. WEST, S.C., COUNTRYMAN, J.K. and HOWARD-FLANDERS, P. (1983). Enzymatic formation of biparental figure-8 molecules from plasmid DNA and their resolution in Escherichia coli. Cell 32, 817-829. WEST, S.C., COUNTRYMAN J.K and HOWARD-FLANDERS, P. (1983). Purification and properties of the RecA protein of Proteus mirabilis . Comparison with E. coli RecA protein; Specificity of interaction with SSB. J. Biol. Chem . 258, 4648-4654. WEST, S.C. and HOWARD-FLANDERS, P. (1983). Formation and resolution of figure-eight recombination intermediates. In "Mechanisms of DNA Replication and Recombination " UCLA Symposium on Molecular and Cellular Biology, New Series, Vol 10, ed. N. Cozzarelli, A.R. Liss Inc., New York p739-751. HOWARD-FLANDERS, P. and WEST, S.C. (1983). Enzymatic mechanism of postreplication repair. In "Cellular Responses to DNA Damage " UCLA Symposium on Molecular and Cellular Biology, New Series, Vol 11, ed. E.C. Friedberg and B.A. Bridges, A.R. Liss Inc., New York p399-407. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1982). Postreplication repair in E. coli; Strand exchange reactions of gapped DNA by RecA protein. Molec. Gen. Genet . 187, 209-217. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1982). The role of SSB protein in RecA promoted branch migration reactions. Molec. Gen. Genet . 186, 333-338. CASSUTO, E., WEST, S.C. and HOWARD-FLANDERS, P. (1982). Can RecA protein promote homologous pairing between duplex regions of DNA. EMBO J . 1, 821-825. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1981). Homologous pairing can occur before DNA strand separation in general genetic recombination. Nature 290, 29-33. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1981). RecA protein promotes homologous pairing and strand exchange reactions between duplex DNA molecules. Proc. Natl. Acad. Sci. USA 78, 2100-2104. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1981). Heteroduplex formation by RecA protein: Polarity of strand exchange. Proc. Natl. Acad. Sci. USA 78, 6149-6154. CASSUTO, E., WEST, S.C., PODELL, J. and HOWARD-FLANDERS, P. (1981). Genetic recombination: RecA protein promotes homologous pairing between duplex DNA molecules without strand unwinding. Nucl. Acid Res . 9, 4201-4211. WEST, S.C., CASSUTO, E. and HOWARD-FLANDERS, P. (1981). Mechanism of E. coli RecA protein-directed strand exchanges in postreplication repair of DNA. Nature 294, 659-662. HOWARD-FLANDERS, P., CASSUTO, E. and WEST, S.C. (1981). Regulatory and enzymatic functions of RecA protein in recombination and postreplication repair. In "Chromosome Damage and Repair " Ed. Seeberg, E. and Kleppe, K., Plenum Press, New York. p169-180. WEST, S.C., CASSUTO, E., MURSALIM, J. and HOWARD-FLANDERS, P. (1980). Recognition of duplex DNA containing single-stranded regions by RecA protein. Proc. Natl. Acad. Sci. USA . 77, 2569-2573. CASSUTO, E., WEST, S.C., MURSALIM, J., CONLON, S. and HOWARD-FLANDERS, P. (1980). Initiation of genetic recombination: Homologous pairing between duplex DNA molecules promoted by RecA protein. Proc. Natl. Acad. Sci. USA . 77, 3962-3966. McKAY, D., STEITZ, T., WEBER, I.T., WEST, S.C. and HOWARD-FLANDERS, P. (1980). Crystallization of monomeric RecA protein. J. Biol. Chem . 255, 6662. CASSUTO, E., WEST, S.C. and HOWARD-FLANDERS, P. (1980). Initiation of genetic recombination: Pairing of duplex DNA molecules promoted by RecA protein. In "Mechanistic Studies of DNA Replication and Genetic Recombination " Ed. Alberts, B. ICN-UCLA Symposia on Molecular and Cellular Biology, Academic Press, New York, Vol. XIX, p871-880. EMMERSON, P.T., NORTHROP, F.D. WALKER, J.E. and WEST, S.C. (1979). Amino terminal sequence of the RecA protein of Escherichia coli . FEBS Letters , 106, 349-351. EMMERSON, P.T., POWELL, K.A., WEST, S.C. and BOTCHERBY, P.K. (1978). The recA gene product of Escherichia coli , an inducible protein. In "DNA Synthesis, Present and Future " Ed. Molineux, I. and Kohiyama, M. NATO Advanced Studies Institutes Series, Life Sciences 17, 979-987. EMMERSON, P.T. and WEST, S.C. (1978). Induction and repression of the recA gene of Escherichia coli. In "DNA Repair Mechanisms " Ed. Hanawalt, P.C., Friedberg, E.C. and Fox, C.F. ICN-UCLA Symposia on Molecular and Cellular Biology, Academic Press, New York, Vol. IX, p367-370. WEST, S.C. and EMMERSON, P.T. (1977). Induction of protein synthesis in Escherichia coli following ultraviolet or gamma irradiation, mitomycin C treatment or by tif expression. Molec. Gen. Genet . 151, 57-67. EMMERSON, P.T. and WEST, S.C. (1977). Identification of protein X of Escherichia coli as the recA/tif gene product. Molec. Gen. Genet. 155, 77-85. WEST, S.C., POWELL, K.A. and EMMERSON, P.T. (1975). RecA-dependent inactivation of the lambda repressor in Escherichia coli lysogens by gamma-irradiation and by tif expression. Molec. Gen. Genet. 141, 1-8.
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