2009
Ahel, D., Horejsi, Z., Wiechens, N., Polo, S.E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S.C., Jackson, S.P. Owen-Hughes, T. and Boulton, S.J. (2009). Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 325, 1240-1243. Poulet, A., Buisson, R., Faivre-Moskalenko, C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Declais, A.-C., Lilley, D.M.J., Ip, S.C.Y., West, S.C., Gilson, E. and Giraud-Panis, M.-J. (2009). TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J. 28, 641-651. West, S.C. (2009). The search for a human Holliday junction resolvase. Biochem. Soc. Trans. 37, 519-526.
2008
Ip, S.C.Y., Rass, U., Blanco, M.G., Flynn, H.R., Skehel, J.M., and West, S.C. (2008). Identification of Holliday junction resolvases from humans and yeast. Nature 456, 357-361. Rass, I., Ahel, I. and West, S.C. (2008). Molecular mechanism of DNA deadenylation by the neurological disease protein Aptataxin. J. Biol. Chem. 283, 33994-34001. Collis, S.J., Ciccia, A., Deans, A.J., Horejsi, Z., Martin, J.S., Maslen, S.L., Skehel, J.M., Elledge, S.J., West, S.C., and Boulton, S.J. (2008). FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell 32, 313-324. Barber, L.J., Youds, J.L., Ward, J.D., McIlwraith, M.J., O'Neil, N.J., Petalcorin, M.I.R., Martin, J.S., Collis, S.J., Cantor, S.B., Auclair, M., Tissenbaum, H., West, S.C., Rose, A.M. and Boulton, S.J. (2008). RTEL maintains genomic stability by suppressing homologous recombination. Cell 135, 261-271. Liu, Y., and West, S.C. (2008). More complexity to the Bloom's syndrome complex. Genes Dev. 22, 2737-2742. Ciccia, A., McDonald, N. and West, S.C. (2008). Structural and functional relationships of the XPF/MUS81 family of proteins. Ann. Rev. Biochem. 77, 259-287. Richard, D.J., Bolderson, E., Cubeddu, L., Wadsworth, R.I.M., Savage, K., Sharma, G.G., Noicolette, M.L., Tsvetanov, S., McIlwraith, M.J., Pandita, R., Takeda, S., Hay, R.T., Gautier, J., West, S.C., Paull, T.T., Pandita, T.K., White, M.F. and Khanna, K.K. (2008). Single-stranded DNA-binding protein hSSB1 is critical for genome stability. Nature 453, 677-681. McIlwraith, M. and West, S.C. (2008). DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Molec. Cell 29, 510-516. Ahel, I., Ahel, D., Matsusaka, T., Clark, A.J., Pines, J., Boulton, S.J. and West, S.C. (2008). Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature 451, 81-85.
2007
Thorslund, T. and West, S.C. (2007) BRCA2: a universal recombinase regulator. Oncogene 26, 7720-7730. Stewart, G.S., Stankovic, T., Byrd, P.J., Wechsler, T., Miller, E.S., Huissoon, A., Drayson, M., West, S.C., Elledge, S.J. and taylor, A.M.R. (2007). RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signalling. Proc. Natl. Acad. Sci. USA 104, 16910-16915 Rass, U., Ahel, I. and West, S.C. (2007). Defective DNA repair and neurodegenerative disease. Cell 130, 991-1004. Esashi, F., Galkin, V.E., Yu, X., Egelman, E.H. and West, S.C. (2007). Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nature Struct. Mol. Biol. 14, 468-474. Thorslund, T., Esashi, T. and West, S.C. (2007). Interactions between human BRCA2 and the meiosis-specific recombinase DMC1. EMBO J. 26, 2915-2922. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A.R., Laghmani, E.H., Joenje, H., MacDonald, N., de Winter, J.P., Wang, W. and West, S.C. (2007). Identification of FAAP24, a novel Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell, 25, 331-343. Rass, U., Ahel, I. and West, S.C. (2007). Actions of Aprataxin in multiple DNA repair pathways. J. Biol. Chem. 282, 9469-9474. Liu, Y., Tarsounas, M., O'Regan, P. and West, S.C. (2007). Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J. Biol. Chem. 282, 1973-1979. Kuznetsov, S., Pellegrini, M., Shuda, K., Fernandez-Capetillo, O., Liu, Y., Martin, B.K., Burkett, S., Southon, E., Pati, D., Tessarollo, L., West, S.C., Donovan, P.J., Nussenzweig, A. and Sharan, S.K. (2007). RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J. Cell Biol. 176, 581-592.
2006
Ahel, I., Rass, U., El-Khamisy, S.F., Katyal, S., Clements, P.M., McKinnon, P.J., Caldecott, K.W. and West, S.C. (2006). The neurodegenerative disease protein Aprataxin resolves abortive DNA ligation intermediates. Nature 443, 713-716. Rodrigue, A., Lafrance, M., Gauthier, M.-C., McDonald, D., Hendzel, M., West, S.C., Jasin, M. and Masson, J.-Y. (2006). Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J. 25, 222-231. Rass, U., and West, S.C. (2006). Synthetic junctions as tools to identify and characterise Holliday junction resolvases. Meth. Enzymol. 408, 485-501.
2005
Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., and West, S.C. (2005). CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature, 434, 598-604. Tarsounas, M., and West, S.C. (2005). Recombination at mammalian telomeres. Cell Cycle 4, 33-35. Galkin, V.E., Esashi, F., Yu, X., Yang, S., West, S.C. and Egelman, E.H. (2005). BRCA2 BRC motifs bind RAD51-DNA filaments. Proc. Natl. Acad. Sci. USA. 102, 8537-8542. McIlwraith, M.J., Vaisman, A., Liu, Y., Fanning, E., Woodgate, R. and West, S.C. (2005). Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates (D-loops) of homologous recombination. Molec. Cell 20, 783-792.
2004
Constantinou, A., and West, S. C.(2004). Holliday junction branch migration and resolution assays. In Methods in Molecular Biology: Genetic Recombination, A. Waldman, ed. (Totowa, New Jersey, Humana Press), pp. 239-253.
Garcia, P. L., Liu, Y., Jiricny, J., West, S. C., and Janscak, P. (2004). Human RecQ5b, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J. 23: 2882-2891.
Hussain, S., Wilson, J. B., Medhurst, A. L., Hejna, J., Witt, E., Anath, A., Davies, A., Masson, J. Y., Moses, R., West, S. C., et al. (2004). Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum. Mol. Genet. 13: 1241-1248.
Liu, Y., Masson, J.-Y., Shah, R., O'Regan, P., and West, S. C. (2004). RAD51C is required for Holliday junction processing in mammalian cells. Science303: 243-246.
Liu, Y., Stasiak, A. Z., Masson, J.-Y., McIlwraith, M. J., Stasiak, A., and West, S. C. (2004). Conformational changes modulate the activity of human RAD51 protein. J. Mol. Biol. 337: 817-827.
Liu, Y., and West, S.C. (2004). Happy Hollidays: 40th anniversary of the Holliday junction. Nat. Rev. Mol. Cell. Biol.5, 937-944.
Surralles, J., Jackson, S. P., Jasin, M., Kastan, M. B., West, S. C., and Joenje, H. (2004). Molecular cross-talk among chromosome fragility syndromes. Genes and Dev. 18: 1359-1370.
Tarsounas, M., Davies, A. A., and West, S. C. (2004). RAD51 localization and activation following DNA damage. Phil. Trans. R. Soc. Lond. B. 359: 87-93.
Tarsounas, M., Muoz, P., Claas, A., Smiraldo, P. G., Pittman, D. L., Blasco, M. A., and West, S. C. (2004). Telomere maintenance requires the RAD51D recombination/repair protein. Cell117: 337-347.
2003
Abraham, J., Lemmers, B., Hande, M. P., Moynahan, M. E., Chahwan, C., Ciccia, A., Essers, J., Hanada, K., Chahwan, R., Khaw, A. K., et al. (2003). Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 22: 6137-6147.
Ciccia, A., Constantinou, A., and West, S. C. (2003). Identification and characterization of the human Mus81/Eme1 endonuclease. J. Biol. Chem. 278: 25172-25178.
Dai, Y., Kysela, B., Hanakahi, L. A., Manolis, K. G., Riballo, E., Stumm, M., Harville, T. O., West, S. C., Oettinger, M. A., and Jeggo, P. A. (2003). Nonhomologous end-joining and V(D)J recombination require an additional factor. Proc. Natl. Acad. Sci. U.S.A. 100: 2462-2467.
Henry-Mowatt, J., Jackson, D., Masson, J.-Y., Johnson, P. A., Clements, P. M., Benson, F. E., Thompson, L. H., Takeda, S., West, S. C., and Caldecott, K. W. (2003). XRCC3 and RAD51 modulate replication fork progression on damaged vertebrate chromosomes. Mol. Cell 11: 1109-1117.
Tarsounas, M., Davies, D., and West, S. C. (2003). BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 22: 1115-1123.
West, S. C. (2003). Cross-links between Fanconi anaemia and BRCA2. DNA Repair 2: 231-234.
West, S. C. (2003). Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell Biol. 4: 1-11.
2002
Chappell, C., Hanakahi, L. A., Karimi-Busheri, F., Weinfeld, M., and West, S. C. (2002). Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J. 21: 2827-2832.
Constantinou, A., Chen, X.-B., McGowan, C. H., and West, S. C. (2002). Holliday junction resolution in human cells: Two junction endonucleases with distinct substrate specificities. EMBO J. 21: 5577-5585.
French, C. A., Masson, J.-Y., Griffin, C. S., O'Regan, P., West, S. C., and Thacker, J. (2002). Role of mammalian RAD51L2 (RAD51C) in recombination and genome stability. J. Biol. Chem. 277: 19322-19330.
Hanakahi, L. A., and West, S. C. (2002). Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J. 21: 2038-2044.
Liu, Y., and West, S. C. (2002). Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res. 4: 9-13.
Singleton, M. R., Wentzell, L. M., Liu, Y., West, S. C., and Wigley, D. B. (2002). Structure of the single-strand annealing domain of human RAD52 protein. Proc. Natl. Acad. Sci. U. S. A. 99: 13492-13497.
2001
Constantinou, A., Davies, A. A., and West, S. C. (2001). Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells. Cell 104: 259-268.
Davies, A. A., Masson, J.-Y., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., and West, S. C. (2001). Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Molec. Cell 7: 273-282.
Masson, J.-Y., Stasiak, A. Z., Stasiak, A., Benson, F. E., and West, S. C. (2001). Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Proc. Natl. Acad. Sci. U.S.A. 98: 8440-8446.
Masson, J.-Y., Tarsounas, M. C., Stasiak, A. Z., Stasiak, A., Shah, R., McIlwraith, M. J., Benson, F. E., and West, S. C. (2001). Identification and purification of two distinct complexes containing the five RAD51 paralogs. Genes Dev. 15: 3296-3307.
Masson, J.-Y., and West, S. C. (2001). The RAD51 and DMC1 recombinases: A non-identical twin relationship. Trends Biochem. Sci. 26: 131-136.
McIlwraith, M. J., Hall, D. R., Stasiak, A. Z., Stasiak, A., Wigley, D. B., and West, S. C. (2001). RadA protein from Archeoglobus fulgidans forms rings, nucleoprotein filaments and catalyses homologous recombination. Nucl. Acids Res. 29: 4509-4517.
McIlwraith, M. J., and West, S. C. (2001). The efficiency of strand invasion by Escherichia coli RecA is dependent upon the length and polarity of ssDNA tails. J. Mol. Biol. 305: 23-31.
Van Dyck, E., Stasiak, A. Z., Stasiak, A., and West, S. C. (2001). Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing. EMBO R. 2: 905-909.
Yu, X., Jacobs, S. A., West, S. C., Ogawa, T., and Egelman, E. H. (2001). Domain structure and dynamics in the helical filaments formed by RecA and RAD51 on DNA. Proc. Natl. Acad. Sci. U.S.A. 98: 8419-8424.
2000
Arenas-Licea, J., van Gool, A. J., Keeley, A. J., Davies, A., West, S. C., and Tsaneva, I. R. (2000). Functional interactions of Mycobacterium leprae RuvA with Escherichia coli RuvB and RuvC on Holliday junctions. J. Mol. Biol. 301: 839-850.
Constantinou, A., Tarsounas, M., Karow, J. K., Brosh, R. M., Bohr, V. A., Hickson, I. D., and West, S. C. (2000). Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO R. 1: 80-84.
Eggleston, A. K., and West, S. C. (2000). Cleavage of Holliday junctions by the Eschericia coli RuvABC complex. J. Biol. Chem. 275: 26467-26476.
George, H., Kuraoka, I., Nauman, D. A., Kobertz, W. R., Wood, R. D., and West, S. C. (2000). RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer. Curr. Biol. 10: 103-106.
Hanakahi, L. A., Bartlet-Jones, M., Chappell, C., Pappin, D., and West, S. C. (2000). Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell 102: 721-729.
Karow, J. K., Constantinou, A., Li, J.-L., West, S. C., and Hickson, I. D. (2000). The Bloom's Syndrome gene product promotes branch migration of Holliday junctions. Proc. Natl. Acad. Sci. U.S.A. 97: 6504-6508.
McIlwraith, M. J., Van Dyck, E., Masson, J.-Y., Stasiak, A. Z., Stasiak, A., and West, S. C. (2000). Reconstitution of the strand invasion step of double-strand break repair using human RAD51, RAD52 and RPA proteins. J. Mol. Biol. 304: 151-164.
Parsons, C. A., Baumann, P., Van Dyck, E., and West, S. C. (2000). Precise binding to single-stranded DNA termini by RAD52 protein. EMBO J. 19: 4175-4181.
Stasiak, A. Z., Larquet, E., Stasiak, A., Mller, S., Engel, A., Van Dyck, E., West, S. C., and Egelman, E. H. (2000). The human RAD52 protein exists as a heptameric ring. Curr. Biol. 10: 337-340.
West, S. C., Chappell, C., Hanakahi, L. A., Masson, J.-Y., McIlwraith, M. J., and Van Dyck, E. (2000). Double-strand break repair in human cells. Cold Spr. Harb. Symp. Quant Biol. 65: 315-321.
Yu, V. P. C. C., Kehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., and Venkitaraman, A. R. (2000). Gross chromosomal rearrangements and genetic exchange between non-homologous chromosomes following BRCA2 inactivation. Genes. Dev. 14: 1400-1406.
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